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Herpes Simplex Virus and Varicella Zoster Virus Infections in Cancer Patients
Viruses. 2023 Feb 5;15(2):439. doi: 10.3390/v15020439.ABSTRACTHerpes simplex virus (HSV) and varicella zoster virus (VZV) are alpha herpesviruses that establish life-long latent infection in neuronal ganglia after primary infection. Periodic reactivation of these viruses results in recurrent infections that can have significant impact on patients' quality of life. HSV commonly causes oral and genital mucocutaneous infections whereas VZV is responsible for varicella/chickenpox and herpes zoster/shingles, but cancer patients are at particularly higher risk of complications including disseminated and visceral infections due t...
Source: Herpes - February 28, 2023 Category: Infectious Diseases Authors: Ralph Tayyar Dora Ho Source Type: research

Reactivation of varicella-zoster virus following mRNA COVID-19 vaccination in a patient with moderately differentiated adenocarcinoma of rectum: A case report
SAGE Open Med Case Rep. 2022 Feb 26;10:2050313X221077737. doi: 10.1177/2050313X221077737. eCollection 2022.ABSTRACTHerpes zoster which is the reactivation of varicella-zoster virus, a pathogenic human alpha-herpes virus, following primary infection or chicken pox, is known to occur especially in advanced age and in the immunocompromised among other predisposing factors. COVID-19 vaccination-induced immunomodulation is a novel scenario, hypothesized to be a result of shifting of T-lymphocyte population towards vaccine-induced naïve CD8+ subset, offsetting the balance of varicella-zoster virus responsive T-helper cells, the...
Source: Cancer Control - March 3, 2022 Category: Cancer & Oncology Authors: B M Munasinghe Upm Fernando M Mathurageethan Durga Sritharan Source Type: research